The absence of high-profile forwards Harry Kane and Zlatan Ibrahimovic will be giving FPL managers the most headaches ahead of game-week 29.
The Manchester United man’s ban and Tottenham Hotspur star’s ankle injury mean around half of the gameís managers are seeking to replace at least one of the pair.
Unsurprisingly, Diego Costa, at £10.6 million, has been the most popular choice with over 124,000 players already drafting in the Chelsea star.
Interestingly Josh King (£5.8m) follows in a close second in terms of transfers in this week.
The Bournemouth manís sparkling form has clearly caught the eye and there is the added bonus of his status as a midfielder in the game.
A meeting with fellow strugglers Swansea City this week makes King a good bet to continue his fine form but he is not the answer to those seeking to replace their main striker.
Romelu Lukaku whose value has now risen to £10.3m is the most obvious alternative to Costa and he will be fancied at home to Hull this Saturday.
Everton however, must then travel to both Liverpool and Manchester United in their subsequent two fixtures.
Sunderland and Southampton both have more manageable immediate schedules which make Manolo Gabbiadini (£6.8m) or Jermain Defoe (£7.7m) strong candidates for the use of a transfer this week.
Those that can afford £12.7m Sergio Aguero meanwhile, should be put off by his average FDR (fixture difficulty ranking) of 4.33 in his next three games.
NMO recommends thinking outside the box however, when looking to fill the Kane/Ibrahimovic void for the short term.
Zlatanís suspension is not Unitedís only worry up front. With Wayne Rooney and Anthony Martial injured, Marcus Rashford looks in line to lead the attack against manager-less Middlesbrough on Sunday.
£6.4m is a low risk outlay on a youngster who is likely to keep his place for the visit of West Brom. Jose Mourinho will also look to Henrikh Mkhitaryan (£8.8m) to provide goals in the absence of the big Swede.
At Spurs meanwhile, the failure of Vincent Janssen to fire during previous Kane absences, will likely mean that midfielder Son Heung-Min could be tasked with leading the line.
The South Korean has already netted seven league goals this term and while he will struggle to replicate Kaneís impact, he could still provide a healthy return of points as Spurs tackle a host of bottom-half teams over the next five weeks.