Tottenham Hotspur will be without two first team stars when they make the trip to Watford on Sunday afternoon, and another will be assessed ahead of the game, according to their official twitter feed.
Spurs have begun the season with a perfect record of three wins from their first three games, the latest of which was a fine victory against Manchester United at Old Trafford on Monday evening.
That win will have buoyed the Tottenham squad, and has certainly ended any lingering criticism of them not dipping into the transfer market at all during the summer.
If Spurs are to maintain their 100% record when they make the short trip to Vicarage Road, then they are going to have to come through without a pair of first team men.
Hugo Lloris has had a tumultuous few days and he is set to miss the match with a thigh injury, while Moussa Sissoko is out with a hamstring problem.
The French goalkeeper has played in all three Premier League matches this term, but his absence will offer up the chance for Michel Vorm to feature between the sticks, while Harry Winks could play a more prominent role in the centre of the park.
Mauricio Pochettino will be without a few other players for the contest with the Hornets. Victor Wanyama is back in full training but the match comes too early for him, as it does Juan Foyth, who is making progress on his injury but who will not feature at Vicarage Road.
The Spurs boss will also give a fitness check to Erik Lamela ahead of the Sunday showdown. He has been suffering with a hamstring issue in the lead up to the match but with the form of Lucas Moura, the attacking star is only expected to play a role from the bench if he is passed fit.