Tottenham Hotspur make their way to St Mary’s Stadium on Saturday afternoon for their FA Cup fourth round tie with Southampton, where they will be without three men and could be missing another, according to their official website.

Spurs head to Hampshire knowing that as well as the Champions League, this is the only piece of silverware they can win this season, something that should ensure Jose Mourinho takes things seriously and names a strong side, despite the Londoners only playing on Wednesday night in the Premier League.

Tottenham overcame Norwich City on that occasion but Harry Winks picked up an ankle injury midway through that match, one which immediately saw him replaced by Eric Dier.

The England international will be assessed ahead of the trip to Southampton to see if he can feature, although looking at him leaving Spurs’ game in midweek you would have to think his participation is in some doubt.

Three men who definitely not be a part of Jose Mourinho’s Tottenham side are Harry Kane, Ben Davies and Moussa Sissoko, a trio who remain on the sidelines with injury and will therefore miss the cup tie.

Spurs had to go to a replay to make it past Championship side Middlesbrough in the third round, and they will hoping for something a little more clinical when they head to St Mary’s on Saturday.

Erik Lamela and Giovani Lo Celso have impressed for Spurs when given the chance in recent outings, and all eyes will be on Mourinho’s team sheet against Southampton to see if the pair are picked in the starting XI.

The winners of the tie will progress to the fifth round, where they will be just two wins away from securing a return to Wembley Stadium in the latter stages of the famous competition.

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