Dele Alli will be absent for Tottenham Hotspurâ€™s Champions League Group H opener against Borussia Dortmund on Wednesday night as he begins a three-match suspension.
The midfielder was sent off as Spurs crashed out of the Europa League to Gent last term, meaning his European ban will start at Wembley against the Germans.
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Elsewhere, the club confirmed on their official website that Victor Wanyama will miss out due to a knee injury; he has sat out the teamâ€™s last two Premier League matches but could be back before the end of the month.
Winger Erik Lamela and full-back Danny Rose remain sidelined with long-term problems, whilst Georges-Kevin Nâ€™Koudou is nearing a return to first-team training.
Manager Mauricio Pochettino will be looking for his side to improve on last yearâ€™s showing in this competition, when they were eliminated from the group stage with just two wins and a draw from six matches.
That he will have to negotiate half of the Group H fixtures without Alli will be an irritation to the Argentine, but one which he has been able to plan for since the youngsterâ€™s dismissal against Gent in February.
Moussa Dembele is likely to be reinstated to the starting XI after appearing only as a substitute in the win at Everton on Saturday, whilst right wing-back Serge Aurier could make his first appearance since joining from Paris Saint-Germain last month.
Getting off to a fast start will be key to Tottenhamâ€™s hopes of progressing from a difficult group which also includes 2016-17 winners Real Madrid and Cypriot champions APOEL Nicosia.
To do so they must break their Wembley hoodoo, which has seen them drop points in both of their Premier League home games so far in the current campaign.
Dortmund sit top of the Bundesliga table after three matches and present a real challenge, but Spurs will be confident of securing a result.