Tottenham Hotspur have confirmed on their official website that six first-team players, including Danny Rose, will not feature against Manchester United on Sunday.
Spurs are set to play their final game at White Hart Lane, with the Premier League side set to move to Wembley next season before their new stadium is ready.
Tottenham can end the campaign unbeaten at home by avoiding defeat against United, while a draw would also confirm a second-place finish for Mauricio Pochettino’s men.
Rose has been on the sidelines for a number of months but there was hope that the England international would be back available for the game against the Red Devils.
However, despite the former Leeds United man being back in team training, a lack of match fitness has prevented the defender in playing.
The report also confirms that Harry Winks and Erik Lamela remain out, while Josh Onomah, Kyle Walker-Peters and Cameron Carter-Vickers are away on national under-20 duty.
Tottenham will hope to record a famous win over United to give White Hart Lane a fitting send-off.