Real Madrid will be without full-back Dani Carvajal and midfielder Isco when they travel to take on La Liga champions Barcelona on Sunday evening.
The pair picked up injuries in the Champions League semi-final victory over Bayern Munich this week and have not been named in the matchday squad, as reported by the club’s official website.
Raphael Varane was also a doubt but he has been selected and should start.
Isco’s absence could leave space on the team sheet for Gareth Bale in what may be his final El Clasico; the Welshman has been strongly linked with a departure from the Spanish capital following another campaign disrupted by injury.
The former Tottenham Hotspur forward has a strong record of 12 goals from just 17 league starts but manager Zinedine Zidane has frequently left him out of the side for key matches, particularly in the Champions League.
Meanwhile, Karim Benzema will hope that he can turn a corner after netting twice against Bayern on Tuesday in what has otherwise been a poor season by the Frenchman’s own high standards.
Cristiano Ronaldo needs just one goal to equal Alfredo Di Stefano’s record tally of 18 for Madrid in El Clasico fixtures.
Rarely in recent years has a meeting between these two sides been of less consequence, with Barca having already taken the La Liga crown with a 4-2 win over Deportivo de La Coruna last weekend.
As for Madrid, they have endured a patchy domestic season that has been saved by yet another run to the Champions League final.
However, they still hold out hopes of overtaking city rivals Atletico to snatch second place, but to do so must surely come away with a win from the Camp Nou.
Fans around the world would have hoped that this would be a title decider with the fixture taking place so close to the end of the campaign, yet sadly it is not the case.
Sparks always fly when Barcelona face Real Madrid and there should still be plenty on show to keep viewers captivated despite it having no bearing on the destination of the championship trophy.