It is the first Old Firm derby of the season on Sunday afternoon when Celtic host Rangers at Celtic Park, and the Gers head into the contest without a key midfielder, according to Sky Sports.
The clash has been a fixture everyone has been looking for to see if there is a power shift in Scottish football, or whether the recent status quo will be maintained, so there will be plenty of eyes on this eagerly anticipated showdown.
Rangers go into the fixture unbeaten under Gerrard and through to the group stages of the Europa League, and victory against their bitter rivals would see them enter the international break above Celtic in the Scottish Premiership table.
If the former Liverpool star is to mastermind victory for the blue half of Glasgow he is going to need all of his credentials, as his side were doing battle in Russia as recently as Thursday evening.
Gerrard will be able to call upon defender Borna Barisic for the contest after he was forced to miss the Europa League qualifier, and he is expected to come into the starting line up.
One man who will not be featuring for Rangers is midfielder Lassana Coulibaly, who remains out with the injury that has seen him miss the last few matches. His absence will be a big blow as the Gers were already without Jamie Murphy and Graham Dorrans, who are both out with long term knee injuries.
The Ibrox boss added to his squad ahead of the transfer deadline when he signed Joe Worrall on loan from Nottingham Forest as well as Eros Grezda. The former could make his debut for his new club in this match, but the latter is awaiting international clearance.
Rangers and Celtic are set to meet a number of times over the course of the campaign, and Gerrard will be eager for his side to lay a real marker down on Sunday.