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Tottenham Hotspur return to Premier League action on Wednesday night with a tough trip to rivals Southampton, who will be motivated to record three points against Spurs.

Visiting manager Mauricio Pochettino, Toby Alderweireld and Victor Wanyama all return to their former employers, in what should add spice to a high-quality encounter.

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Spurs recorded back-to-back home wins over the lead up to Christmas against Hull City and Burnley, with the major question ahead of the game on the south coast whether the North London side will play a back four or a three-man defence.

Alderweireld has been passed fit to play and will surely either take the place of Eric Dier or slot in beside the England international and Jan Vertonghen.

As such, from the team that beat Burnley last time out, it may well be rising star Harry Winks that makes way to house the returning Belgian enforcer.

Predicted Tottenham XI vs Saints (3-5-2): Lloris; Dier, Alderweireld, Vertonghen; Walker, Wanyama, Dembele, Eriksen, Rose; Alli, Kane