Tottenham Hotspur and England forward Harry Kane may have damaged ankle ligaments against Manchester United and could face a spell on the sidelines, reports The Daily Mirror.
The Spurs striker suffered the injury to his left foot when he was tackled by Phil Jones shortly before the end of the match.
Losing the striker would be bad enough for Tottenham but it comes at a time when they already face a string of matches without Heung-Min Son.
The South Korean is on duty at the Asia Cup and Spurs are also without Eric Dier, Mousa Dembele, Lucas Moura, Moussa Sissoko and Victor Wanyama.
It means Mauricio Pochettino must rely on the depth of his squad as Tottenham prepare to play Fulham and Watford in the Premier League later this month.
The Spurs coaching team will also be nervously awaiting results of scans on Kane’s foot given his previous issues.
He missed two matches last season and had two separate spells on the sidelines the season before with ankle injuries – although they were on his right foot, not his left.
The blow capped a bad day for Spurs, who were beaten 1-0 at Wembley with Marcus Rashford’s first-half strike proving decisive.
Kane was one of several Tottenham players frustrated by an inspired performance by United goalkeeper David De Gea.
Pochettino has admitted that the early prognosis is not good.
“My worry is that it was a bad tackle in the last moment. It wasn’t the intention of the United player but it was a bad tackle and now he has bit of a swelling on his ankle and he was limping after the game,” the Tottenham boss said.
“We’ll see what happens with Kane. He suffered a big tackle and twisted his ankle. We need to assess him.
“We are going to lose Son for the Asia Cup and if Harry Kane suffers an injury, it is going to be massive for us.”
Spurs have now lost four matches at home this season and as a result, lost more ground on Premier League leaders Liverpool and Manchester City.
If Kane is out for an extended period then Tottenham will have to turn to Fernando Llorente to lead the line in his absence.