Mauricio Pochettino has a whole host of players missing when his Tottenham Hotspur team face PSV Eindhoven in a Champions League clash they must win at Wembley Stadium on Tuesday evening, according to their official website.
The Spurs boss has seen his team pick up just one point from their opening three matches in the competition, and if they are to have any chance of remaining in Europe after Christmas, victory against the Dutch side will be paramount.
Pochettino already knew he was going to be missing his captain Hugo Lloris for the fixture, after the influential goalkeeper was sent off in the reverse meeting in Eindhoven. He will be suspended for this match as a result of that.
That is only the start of his problems however, as he is going to be without a number of defenders and midfielders for the clash as well.
Jan Vertonghen, Danny Rose, Eric Dier and Victor Wanyama all missed the win over Wolverhampton Wanderers on Saturday evening but that victory came at a cost.
That is because Pochettino lost Mousa Dembele to an ankle injury, and while the extent of the issue is not yet known, it has been determined that he will not feature against the Dutchmen at Wembley.
The Spurs boss will need to choose between Michel Vorm and Paulo Gazzaniga as to who will replace Lloris between the sticks, with the former the man most likely to be chosen.
It remains to be seen who he will go with in the heart of his midfield, although Harry Winks will be expected to get another outing in the Champions League, given the lack of options available to Pochettino in that area.
There is one crumb of comfort for the Tottenham manager, as Dele Alli is expected to be fit to feature against the Eredivisie outfit, despite missing the win at Molineux over the weekend.