Nottingham Forest will be unable to call on four players when they begin their 2017-18 Championship campaign by hosting Millwall this evening.
Matty Cash, Danny Fox, Stephen Henderson and Jamie Ward are all unavailable to boss Mark Warburton.
Nevertheless, Forest go into the match full of confidence after an unbeaten pre-season and fans – in their numbers – heading to the City Ground will be in expectant mood.
While Fox and Henderson are long-term absentees, Cash and Ward picked up injuries during the Nottingham side’s recent friendlies.
Cash suffered an ankle ligament injury against Girona and could be on the sidelines for as much as three months.
For the 19-year-old, it is a case of history repeating itself as he missed a large chunk of last season’s campaign with a leg fracture.
Ward, meanwhile, is expected to be out of action for between four and six weeks with a calf injury he picked up against Burnley.
“Matty Cash and Jamie Ward are injured, unfortunately, as you will be aware,” Warburton told The Nottingham Post.
“Jamie was actually trying to avoid an injury against Burnley, but ended up coming off worse, with a freak injury.”
And while goalkeeper Henderson and left-back Fox are still unavailable, they are back in training as they return from their injury problems.
Warburton hopes the fans will turn up in their numbers and get behind the Reds as their latest bid for promotion to the Premier League gets underway.
“I hope it is a full house here on Friday,” he told the club’s official website.
“The backing in terms of season cards is outstanding, and early as well. The fans showed their backing and belief and the players respond to that.
“The players are well aware of those figures and they know what they have to do.
“They have a responsibility to excite the fans and this club needs to be moving up the table.
“It is great to have their backing and we have to maintain the quality of performance to keep that backing in place and I hope every time we play here we have nearly a full house.”
Forest have made a number of signings during the summer transfer window, including forward Daryl Murphy from Newcastle United and winger Barrie McKay from Rangers.
Both are likely to start while Kieran Dowell, a recent loan signing from Everton to add midfield cover may also feature.
Millwall were promoted via the League One play-offs last season and will themselves be fielding a number of new players.